Publications

 

  1. Cryo X-ray microscope with flat sample geometry for correlative fluorescence and nanoscale tomographic imaging. Gerd Schneider, Peter Guttmann, Stefan Rehbein, Stephan Werner and Rolf Follath. Journal of Structural Biology, Vol 177, Issue 2, February 2012, pp 212-223.

 

  1. The Molecular Mechanism of Thermostable α-Galactosidases AgaA and AgaB Explained by X-ray Crystallography and Mutational Studies. Romain Merceron, Marine Foucault, Richard Haser, Ralf Mattes, Hildegard Watzlawick andPatrice Gouet. JBC, 2012, 287, pp 39642-39652.

 

  1. Library methods for structural biology of challenging proteins and their complexes. Darren J. Hart and Geoffrey S. Waldo. Curr. Opin. Struct. Biol., Vol 23, Issue 3, June 2013, pp 403-406.

 

  1. Expression, purification and crystallization of the C-terminal LRR domain of Streptococcus pyogenes protein 0843. T. Haikarainen, V. Loimaranta, C. Prieto-Lopez, P. Battula, J. Finne and A. C. Papageorgiou. Acta Cryst., 2013, F69, pp 559-561.

 

  1. Inhibition of Leishmania infantum Trypanothione Reductase by Azole-Based Compounds: a Comparative Analysis with Its Physiological Substrate by X-ray Crystallography. Paola Baiocco, Giovanna Poce, Salvatore Alfonso, Martina Cocozza, Giulio Cesare Porretta, Gianni Colotti, Mariangela Biava, Francesca Moraca, Maurizio Botta, Vanessa Yardley, Annarita Fiorillo, Antonella Lantella, Francesco Malatesta and Andrea Ilari. ChemMedChem, Vol 8, Issue 7, July 2013, pp 1175–1183.

 

  1. Quaternary structure of human, Drosophila melanogaster and Caenorhabditis elegans MFE-2 in solution from synchrotron small-angle X-ray scattering. Maija L. Mehtäläa, Tatu J.K. Haatajaa, Clément E. Blanchet,J. Kalervo Hiltunena, Dmitri I. Svergun and Tuomo Glumoff. FEBS Letters, Volume 587, Issue 4, February 2013, pp 305-310.

 

  1. Impact and progress in small and wide angle X-ray scattering (SAXS and WAXS). Melissa A Graewert and Dmitri I Svergun. Curr. Opin. Struct. Biol., Vol 23, Issue 5, October 2013, pp 748–754.

 

  1. Access channel residues Ser315 and Asp137 in Mycobacterium tuberculosis catalase-peroxidase (KatG) control peroxidatic activation of the pro-drug isoniazid. Xiangbo Zhao,Hans-Petter Hersleth,Janan Zhu,K.Kristoffer Andersson and Richard S. Magliozzo. Chem. Commun., 2013, 49, pp 11650-11652.

 

  1. Structural Basis and Selectivity of Tankyrase Inhibition by a Wnt Signaling Inhibitor WIKI4. Teemu Haikarainen, Harikanth Venkannagari,Mohit Narwal, Ezeogo Obaji, Hao-Wei Lee, Yves Nkizinkiko and Lari Lehtiö. PLOS One, June 2013.

 

  1. para-Substituted 2-Phenyl-3,4-dihydroquinazolin-4-ones As Potent and Selective Tankyrase Inhibitors. Dr. Teemu Haikarainen, Dr. Jarkko Koivunen, Mohit Narwal, Harikanth Venkannagari, Ezeogo Obaji, Päivi Joensuu, Prof. Taina Pihlajaniemi, Dr. Lari Lehtiö. ChemMedChem, Vol 8, Issue 12, December 2013, pp 1978–1985.

 

  1. Biochemical analysis and structure determination of Paucimonas lemoignei poly(3-hydroxybutyrate) (PHB) depolymerase PhaZ7 muteins reveal the PHB binding site and details of substrate–enzyme interactions. Dieter Jendrossek, Siska Hermawan1, Bishwa Subedi and Anastassios C. Papageorgiou. Molecular Microbiology, Vol 90, Issue 3, November 2013, pp 649-664.

 

  1. Reconstruction of Quaternary Structure from X-ray Scattering by Equilibrium Mixtures of Biological Macromolecules. Maxim V. Petoukhov, Isabelle M.L. Billas, Maria Takacs, Melissa A. Graewert, Dino Moras, and Dmitri I. Svergun. Biochemistry, 2013, 52, pp 6844 − 6855.

 

  1. Structures of Wnt-Antagonist ZNRF3 and Its Complex with R-Spondin 1 and Implications for Signaling.  Weng Chuan Peng, Wim de Lau, Pramod K. Madoori, Federico Forneris, Joke C. M. Granneman, Hans Clevers and Piet Gros. PLOS One, December 2013, Vol 8, Issue 12, e83110.

 

  1. Nanoscale spectroscopy and tomography with the HZB X-ray microscope: Applications in materials and life sciences. P Guttmann et al 2013 J. Phys.: Conf. Ser. 463 012032.

 

  1. Structure and Conformational Dynamics of DMPC/Dicationic Surfactant and DMPC/Dicationic Surfactant/DNA Systems. Zuzanna Pietralik, Rafał Krzysztoń, Wojciech Kida, Weronika Andrzejewska and Maciej Kozak. Int. J. Mol. Sci. 2013, 14, pp 7642-7659.

 

  1. Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5. Weng Chuan Peng, Wim de Lau, Federico Forneris, Joke C.M. Granneman, Meritxell Huch, Hans Clevers and Piet Gros. Cell Reports, June 2013, Vol 3, Issue 6, pp 1885 - 1892.

 

  1. TraG Encoded by the pIP501 Type IV Secretion System Is a Two-Domain Peptidoglycan-Degrading Enzyme Essential for Conjugative Transfer. Karsten Arends, Ertugrul-Kaan Celik, Ines Probst, Nikolaus Goessweiner-Mohr, Christian Fercher, Lukas Grumet, Cem Soellue, Mohammad Yaser Abajy, Tuerkan Sakinc, Melanie Broszat, Katarzyna Schiwon, Guenther Koraimann, Walter Kellerb and Elisabeth Grohmann. J. Bacteriol. October 2013, Vol 195, no. 19, pp 4436-4444.

 

  1. Structural Characterization of Nitrosomonas europaea Cytochrome c-552 Variants with Marked Differences in Electronic Structure. Mehmet Can, Jolanta Krucinska, Giorgio Zoppellaro, Niels H. Andersen, Joseph E. Wedekind, Hans-Petter Hersleth, K. Kristoffer Andersson and Kara L. Bren. ChemBioChem, 2013, 14, pp 1828–1838.

 

  1. Ligand binding and aggregation of pathogenic SOD1.  Gareth S.A. Wright,    Svetlana V. Antonyuk, Neil M. Kershaw, Richard W. Strange and S Samar Hasnain. Nature Communications 4, April 2013, Article no 1758.

 

  1. Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights. G. Róna, M. Marfori, M. Borsos, I. Scheer, E. Takács, J. Tóth, F. Babos, A. Magyar, A. Erdei, Z. Bozóky, L. Buday, B. Kobe and B. G. Vértessy. Acta Cryst. (2013), D69, pp 2495-2505.

 

  1. Adaptation of Aminoacyl-tRNA Synthetase Catalytic Core to Carrier Protein Aminoacylation. Marko Mocibob, Nives Ivic, Marija Luic and Ivana Weygand-Durasevic. Structure, Vol 21, Issue 4, April 2013, pp 614-626.

 

  1. Crystallographic identification of an unexpected protein complex in silkworm haemolymph. A. J. Pietrzyk, A. Bujacz, J. Mueller-Dieckmann, M. Lochynska, M. Jaskolski and G. Bujacz. Acta Cryst. (2013), D69, pp 2353-2364.

 

  1. Structure and enzymatic mechanism of a moonlighting dUTPase. Leveles, I. Nemeth, V., Szabo, J.E. Harmat, V. Nyıri, K. Bendes, A.A., Papp-Kadar V., Zagyva, I. Rona, G.,Ozohanics, O., Vekey, K., Toth, J., and Vertessy, B.G. Acta Cryst. (2013), D69.

 

  1. Crystal and Solution Studies of the “Plus-C” Odorant-binding Protein 48 from Anopheles gambiae. CONTROL OF BINDING SPECIFICITY THROUGH THREE-DIMENSIONAL DOMAIN SWAPPING. Katerina E. Tsitsanou, Christina E. Drakou, Trias Thireou, Anna Vitlin Gruber, Georgia Kythreoti, Abdussalam Azem, Dimitrios Fessas, Elias Eliopoulos, Kostas Iatrou‖ and Spyros E. Zographos. JBC, 288, November 2013, pp 33427-33438.

 

  1. Switching between the Alternative Structures and Functions of a 2-Cys Peroxiredoxin, by Site-Directed Mutagenesis. F. Angelucci1, F. Saccocci, M. Ardini, G. Boumis, M. Brunori, L. Di Leandro, R. Ippoliti, A.E. Miele, G. Natoli, S. Scotti and A. Bellelli. J. Mol. Biol. (2013), 425, pp 4556-4568.

 

  1. Structural Basis of a Rationally Rewired Protein-Protein Interface Critical to Bacterial Signaling. Anna I. Podgornaia, Patricia Casino, Alberto Marina and Michael T. Laub. Structure, Vol 21, Issue 9, September 2013, pp 1636-1647.

 

  1. Biophysical characterization and crystal structure of the Feline Immunodeficiency Virus p15 matrix protein. Jennifer Serrière, Xavier Robert, Magali Perez, Patrice Gouet and Christophe Guillon. Retrovirology, 2013, 10:64.

 

  1. Structure and enzymatic mechanism of a moonlighting dUTPase. I. Leveles, V. Németh, J. E. Szabó, V. Harmat, K. Nyíri, Á.Á. Bendes, V. Papp-Kádár, I. Zagyva, G. Róna, O. Ozohanics, K. Vékey, J. Tóth and B. G. Vértessy. Acta Cryst. (2013), D69, pp 2298-2308.

 

  1. A molecular explanation for the recessive nature of parkin-linked Parkinson’s disease.  Donald E. Spratt, R Julio Martinez-Torres, Yeong J. Noh, Pascal Mercier, Noah Manczyk, Kathryn R. Barber, Jacob D. Aguirre, Lynn Burchell, Andrew Purkiss, Helen Walden & Gary S. Shaw. Nature Communications 4, Article number:1983, June 2013.

 

  1. Optimization of protein purification and characterization using Thermofluor screens. Stephane Boivin, Sandra Kozak and Rob Meijers. Protein Expression and Purification 91 (2013), pp 192-206.

 

  1. Structure–function relationships of two paralogous single-stranded DNA-binding proteins from Streptomyces coelicolor: implication of SsbB in chromosome segregation during sporulation. Tina Paradzik, Nives Ivic, Zelimira Filic,Babu A. Manjasetty,Paul Herron, Marija Luic and Dusica Vujaklija. Nucl. Acids Res. (2013), 41 (6): pp 3659-3672.

 

  1. Discovery of Tankyrase Inhibiting Flavones with Increased Potency and Isoenzyme Selectivity. Mohit Narwal, Jarkko Koivunen, Teemu Haikarainen, Ezeogo Obaji, Ongey E. Legala, Harikanth Venkannagari, Päivi Joensuu, Taina Pihlajaniemi, and Lari Lehtiö. J. Med. Chem. 2013, 56 (20), pp 7880–7889.

 

  1. Conjugative type IV secretion systems in Gram-positive bacteria. Nikolaus Goessweiner-Mohr, Karsten Arends, Walter Kellera and Elisabeth Grohmann. Plasmid, Vol 70, Issue 3, November 2013, pp 289 - 302.

 

  1. Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation. Flora S. Groothuizen, Alexander Fish, Maxim V. Petoukhov, Annet Reumer, Laura Manelyte, Herrie H. K. Winterwerp, Martin G. Marinus, Joyce H. G. Lebbink, Dmitri I. Svergun, Peter Friedhoff3 and Titia K. Sixma. Nucl. Acids Res. (2013), 41, (17): pp 8166-8181.

 

  1. Cryo-soft X-ray tomography: a journey into the world of the native-state cell. Raffaella Carzaniga, Marie-Charlotte Domart, Lucy M. Collinson and Elizabeth Duke. Protoplasma (2014) 251, pp 449-458.

 

  1. Structural Data on the Periplasmic Aldehyde Oxidoreductase PaoABC from Escherichia coli: SAXS and Preliminary X-ray Crystallography Analysis.Ana Rita Otrelo-Cardoso, Márcia Alexandra da Silva Correia, Viola Schwuchow, Dmitri I. Svergun, Maria João Romão, Silke Leimkühler and Teresa Santos-Silva. Int. J. Mol. Sci., 2014, 15, pp 2223-2236.

 

  1. Crystal structure and biochemical characterization of a manganese superoxide dismutase from Chaetomium thermophilum. Teemu Haikarainena, Clémence Frioux, Li-Qing Zhnag, Duo-Chuan Li and Anastassios C. Papageorgiou. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol 1844, Issue 2, February 2014, pp 422-429.

 

  1. Cytochrome c6B of Synechococcus sp. WH 8102 – Crystal structure and basic properties of novel c6-like family representative. Pawel Zatwarnicki, Jakub Barciszewski, Szymon Krzywda, Mariusz Jaskolski, Piotr Kolesinski and Andrzej Szczepaniak. Biochemical and Biophysical Research Communications, Vol 443, Issue 4, January 2014, pp 1131-1136.

 

  1. A cool hybrid approach to the herpesvirus ‘life’ cycle. Tzviya Zeev-Ben-Mordehai, Christoph Hagen and Kay Grünewald . Curr. Opin. Virol., Vol 5, April 2014, pp 42-49.

 

  1. Imaging endosomes and autophagosomes in whole mammalian cells using correlative cryo-fluorescence and cryo-soft X-ray microscopy (cryo-CLXM). Elizabeth M.H. Duke, Minoo Razi, Anne Weston, Peter Guttmann, Stephan Werner, Katja Henzler, Gerd Schneider, Sharon A. Tooze and Lucy M. Collinson. Ultramicroscopy, Vol 143, August 2014, pp 77-78.

 

  1. Crystal structures of substrate-bound chitinase from the psychrophilic bacterium Moritella marina and its structure in solution. P. H. Malecki, C. E. Vorgias, M. V. Petoukhov, D. I. Svergun and W. Rypniewski. Acta Crystallographica Section D, Biological Crystallography, Vol 70, Part 3, March 2014.

 

  1. Structural and Functional Insights into Peptidoglycan Access for the Lytic Amidase LytA of Streptococcus pneumoniae. Peter Mellroth, Tatyana Sandalova, Alexey Kikhney, Francisco Vilaplana, Dusan Hesek, Mijoon Lee, Shahriar Mobashery, Staffan Normark, Dmitri Svergun, Birgitta Henriques-Normarka and Adnane Achour. mBio vol. 5 no. 1 February 2014, e01120-13.
     
  2. The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold. Tim Schulte, Jonas Löfling, Cecilia Mikaelsson, Alexey Kikhney, Karina Hentrich, Aurora Diamante, Christine Ebel, Staffan Normark, Dmitri Svergun, Birgitta Henriques-Normark and Adnane Achour.  Open Biol. January 2014.

 

  1. Biochemical and biological assessment of the inhibitory potency of extracts from vinification byproducts of Vitis vinifera extracts against glycogen phosphorylase. Anastassia L. Kantsadi, Anna Apostolou, Stavroula Theofanous, George A. Stravodimos, Efthimios Kyriakis, Vyron A. Gorgogietas, Demetra S.M. Chatzileontiadou, Kalliope Pegiou, Vassiliki T. Skamnaki, Dimitrios Stagos, Dimitrios Kouretas, Anna-Maria G. Psarra, Serkos A. Haroutounian and Demetres D. Leonidas. Food and Chemical Toxicology, Vol 67, May 2014, pp 35–43.

 

  1. Ensemble refinement shows conformational flexibility in crystal structures of human complement factor D. F. Forneris, B. T. Burnley and P. Gros. Acta Cryst. (2014), D70, pp 733-743.

 

  1. The Salmonella enterica ZinT structure, zinc affinity and interaction with the high-affinity uptake protein ZnuA provide insight into the management of periplasmic zinc. Andrea Ilari, Flaminia Alaleona, Giancarlo Tria, Patrizia Petrarca, Andrea Battistoni, Carlotta Zamparelli, Daniela Verzili, Mattia Falconi and Emilia Chiancone. Biochimica et Biophysica Acta (BBA) - General Subjects, Vol 1840, Issue 1, January 2014, pp 535–544.

 

  1. The structure of a purple acid phosphatase involved in plant growth and pathogen defence exhibits a novel immunoglobulin-like fold. S. V. Antonyuk, M. Olczak, T. Olczak, J. Ciuraszkiewicz and R. W. Strange. IUCrJ (2014), 1, pp 101-109.

 

  1. Identification of the first small-molecule ligand of the neuronal receptor sortilin and structure determination of the receptor-ligand complex.  J. L. Andersen, T. J. Schrøder, S. Christensen, D. Strandbygård, L. T. Pallesen, M. M. García-Alai, S. Lindberg, M. Langgård, J. C. Eskildsen, L. David, L. Tagmose, K. B. Simonsen, P. J. Maltas, L. C. B. Rønn, I. E. M. de Jong, I. J. Malik, J. Egebjerg, J.-J. Karlsson, S. Uppalanchi, D. R. Sakumudi, P. Eradi, S. P. Watson and S. Thirup. Acta Cryst. (2014), D70, pp 451-460.

 

  1. Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors. Teemu Haikarainen, Mohit Narwal, Päivi Joensuu and Lari Lehtiö. ACSMed.Chem.Lett. 2014, 5, pp 18-22.
     
  1. Interchanging Geometry Conventions in 3DEM: Mathematical Context for the Development of Standards.C. O. S. Sorzano,R. Marabini,J. Vargas,J. Otón,J. Cuenca-Alba,A. Quintana,J. M. de la Rosa-Trevín, and J. M. Carazo.Computational Methods for Three-Dimensional Microscopy Reconstruction Applied and Numerical Harmonic Analysis 2014, pp 7-42.

 

  1. Discovery of a New Binding Site on Human Choline Kinase α1: Design, Synthesis, Crystallographic Studies, and Biological Evaluation of Asymmetrical Bispyridinium Derivatives. Belén Rubio-Ruiz, Ainoa Figuerola-Conchas, Javier Ramos-Torrecillas, Fermín Capitán-Cañadas, Pablo Ríos-Marco, Ma Paz Carrasco, Miguel Ángel Gallo, Antonio Espinosa, Carmen Marco, Concepción Ruiz, Antonio Entrena, Ramon Hurtado-Guerrero and Ana Conejo-García.J. Med. Chem., 2014, 57 (2), pp 507–515.

 

  1. Visualizing autophosphorylation in histidine kinases. Patricia Casino, Laura Miguel-Romero and Alberto Marina. Nature Communications 5 (2014), Article number: 3258.

 

  1. Crystal Structure of Bacillus cereus Class Ib Ribonucleotide Reductase Di-iron NrdF in Complex with NrdI. Marta Hammerstad, Hans-Petter Hersleth, Ane B. Tomter, Åsmund K. Røhr and K. Kristoffer Andersson. ACS Chem. Biol., 2014, 9 (2), pp 526–537.

 

  1. Study of Complex Thermosensitive Amphiphilic Polyoxazolines and Their Interaction with Ionic Surfactants. Are Hydrophobic, Thermosensitive, and Hydrophilic Moieties Equally Important? A. Bogomolova, S.K. Filippov, L. Starovoytova, B. Angelov, P. Konarev, O. Sedlacek, M. Hruby and P. Stepanek. J. Phys. Chem. B,Article ASAP, April 2014.

 

  1. Purification, crystallization and preliminary X-ray characterization of the third ScaB cohesin in complex with an ScaA X-dockerin from Acetivibrio cellulolyticus. K. Cameron, V. D. Alves, P. Bule, L. M. A. Ferreira, C. M. G. A. Fontes and S. Najmudin.Acta Cryst. (2014), F70, pp 656-658.

 

  1. Crystallization and preliminary X-ray crystallographic analysis of a novel α-L-arabinofuranosidase (CtGH43) from Clostridium thermocellum ATCC 27405
    A. Goyal, S. Ahmed, C. M. G. A. Fontes and S. Najmudin. Acta Cryst. (2014), F70, pp 616-618.

 

  1. Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life. James A. Austin, Gareth S. A. Wright, Seiji Watanabe, J. Günter Grossmann, Svetlana V. Antonyuk, Koji Yamanaka, and S. Samar Hasnain. PNAS (2014), Vol111 no.11, pp 4309-4314.

 

  1. A Comprehensive Mechanism of Fibrin Network Formation Involving Early Branching and Delayed Single- to Double-Strand Transition from Coupled Time-Resolved X-ray/Light-Scattering Detection. Mattia Rocco, Matteo Molteni, Marco Ponassi, Guido Giachi, Marco Frediani, Alexandros Koutsioubas, Aldo Profumo, Didier Trevarin, Barbara Cardinali, Patrice Vachette, Fabio Ferri and Javier Pérez. J. Am. Chem. Soc., (2014), 136 (14), pp 5376–5384.

 

  1. Overproduction, purification, crystallization and preliminary X-ray characterization of the family 46 carbohydrate-binding module (CBM46) of endo-β-1,4-glucanase B (CelB) from Bacillus halodurans. I. Venditto, H. Santos, L. M. A. Ferreira, K. Sakka, C. M. G. A. Fontes and S. Najmudin. Acta Crystallographica Section F, Structural Biology Communications, (2014) Vol 70, Part 6.

 

  1. Multimodal nanoparticles as alignment and correlation markers in fluorescence/soft X-ray cryo-microscopy/tomography of nucleoplasmic reticulum and apoptosis in mammalian cells. Christoph Hagen, Stephan Werner, Susana Carregal-Romero, Ashraf N. Malhas, Barbara G. Klupp, Peter Guttmann, Stefan Rehbein, Katja Henzler, Thomas C. Mettenleiter, David J. Vaux, Wolfgang J. Parak, Gerd Schneider and Kay Grunewald. Ultramicroscopy, June 2014.

 

  1. Structural and Biophysical Characterization of Murine Rif1 C Terminus Reveals High Specificity for DNA Cruciform Structures. Rasa Sukackaite, Malene Ringkjøbing Jensen, Philippe J. Mas, Martin Blackledge, Sara B. Buonomo and Darren J. Hart. JBC,  289, pp 13903-13911.

 

  1. Composite Aromatic Boxes for Enzymatic Transformations of Quaternary Ammonium Substrates. Gergely N. Nagy, Lívia Marton, Alicia Contet,Dr. Olivér Ozohanics, Laura-Mihaela Ardelean, Dr. Ágnes Révész, Prof. Károly Vékey, Prof. Florin Dan Irimie, Dr. Henri Vial, Dr. Rachel Cerdan and Beáta G. Vértessy. Angewandte Chemie, October 2014, DOI: 10.1002/ange.201408246.

 

  1. T Cells Kill Bacteria Captured by Transinfection from Dendritic Cells and Confer Protection in Mice. Aránzazu Cruz-Adalia, Guillermo Ramirez-Santiago, Carmen Calabia-Linares, Mónica Torres-Torresano1, Lidia Feo, Marta Galán-Díez, Elena Fernández-Ruiz, Eva Pereiro, Peter Guttmann, Michele Chiappi, Gerd Schneider, José López Carrascosa, Francisco Javier Chichón, Gloria Martínez del Hoyo, Francisco Sánchez-Madrid and Esteban Veiga. Cell Host & Microbe, Vol 15, Issue 5, 14 May 2014, pp 611–622.

 

  1. Structural and Biochemical Characterization of the Folyl-poly-γ-L-glutamate Hydrolyzing Activity of Human Glutamate Carboxypeptidase II. Michal Navrátil, Jakub Ptáček, Pavel Šácha, Jana Starková, Jacek Lubkowski, Cyril Bařinka and Jan Konvalinka. FEBS J. DOI: 10.1111/febs.12857.

 

  1. Engineering the internal cavity of neuroglobin demonstrates the role of the haem-sliding mechanism. G. Avella, C. Ardiccioni, A. Scaglione, T. Moschetti, C. Rondinelli, L. C. Montemiglio, C. Savino, A. Giuffrè, M. Brunori and B. Vallone. Acta Cryst. (2014), D70, pp 1640-1648.

 

  1. The unique regulation of iron-sulfur cluster biogenesis in a Gram-positive bacterium. Joana A. Santos, Noelia Alonso-García, Sandra Macedo-Ribeiro, and Pedro José Barbosa Pereira. PNAS, Vol 111 no. 22.

 

  1. Overexpression, purification, crystallization and preliminary X-ray characterization of the fourth scaffoldin A cohesin from Acetivibrio cellulolyticus in complex with a dockerin from a family 5 glycoside hydrolase. Pedro Bule, Ana Correia, Kate Cameron, Victor D. Alves, Vânia Cardoso, Carlos M. G. A. Fontesa and Shabir Najmudina. Acta Cryst. (2014), F70, pp 1065-1067.

 

  1. Overexpression, crystallization and preliminary X-ray characterization of Ruminococcus flavefaciens scaffoldin C cohesin in complex with a dockerin from an uncharacterized CBM-containing protein. Pedro Bule, Vered Ruimy-Israeli, Vânia Cardoso, Edward A. Bayer, Carlos M. G. A. Fontesa and Shabir Najmudin. Acta Cryst. Section F, Vol 70, Part 8, August 2014, pp 1061-1064.

 

  1. Crystallization and preliminary X-ray diffraction analysis of a trimodular endo-β-1,4-glucanase (Cel5B) from Bacillus halodurans. I. Venditto, H. Santos, J. Sandy, J. Sanchez-Weatherby, L. M. A. Ferreira, K. Sakka, C. M. G. A. Fontes and S. Najmudin. Acta Cryst. (2014), F70.

 

  1. Crystallization and preliminary X-ray diffraction studies of the C-terminal domain of Chlamydia trachomatis CdsD. Gitte Meriläinen and Rik K. Wierenga. Acta Cryst. (2014), F70, Part 10, pp 1431-1433.

 

  1. Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the extracellular olfactomedin domain of gliomedin. H. Han, P. Kursula. Acta Cryst. (2014), F70, Part 11, pp 1536-1539.

 

  1. Crystallization and preliminary X-ray crystallographic analysis of polyphenol oxidase from Juglans regia (jrPPO1). F. Zekiri, A. Bijelic, C. Molitor and A. Rompel. Acta Cryst. (2014) F70, Part 6, pp832-834.

 

  1. Expression, purification and crystallization of a novel carbohydrate-binding module from the Ruminococcus flavefaciens cellulosome. I. Venditto, M. S. J. Centeno, L. M. A. Ferreira, C. M. G. A. Fontes and S. Najmudin. Acta Cryst. (2014), F70, Part 12.

 

  1. Biological applications of cryo‐soft X‐ray tomography. E. Duke, K. Dent, M. Razi, L.M. Collinson. Journal of Microscopy, August 2014, Vol 255, Issue 2, pp 65-70.

 

  1. The Crystal Structure of Netrin-1 in Complex with DCC Reveals the Bifunctionality of Netrin-1 As a Guidance Cue. Lorenzo I. Finci, Nina Krüger, Xiaqin Sun, Jie Zhang, Magda Chegkazi, Yu Wu, Gundolf Schenk, Haydyn D.T. Mertens, Dmitri I. Svergun, Yan Zhang, Jia-huai Wang, Rob Meijers. Neuron, August 2014, Vol 83, Issue 4, pp 839-849.

 

  1. Non-contact Current Transfer Induces the Formation and Improves the X-ray Diffraction Quality of Protein Crystals. Ilias Boltsis, George Lagoumintzis, Demetra S.M. Chatzileontiadou, Petros Giastas, Socrates J. Tzartos, Demetres D. Leonidas and Konstantinos Poulas. Cryst. Growth Des., 2014, 14(9), pp 4347-4354.

 

  1. Substrate-Guided Front-Face Reaction Revealed by Combined Structural Snapshots and Metadynamics for the Polypeptide N-Acetylgalactosaminyltransferase 2. Erandi Lira-Navarrete, Javier Iglesias-Fernández, Dr. Wesley F. Zandberg, Ismael Compañón, Yun Kong, Dr. Francisco Corzana, Prof. B. Mario Pinto, Prof. Henrik Clausen, Prof. Jesús M. Peregrina, Prof. David J. Vocadlo, Prof. Carme Rovira and Dr. Ramon Hurtado-Guerrero. Angewandte Chemie, July 2014, Vol 126, Issue 31, pp 8345-8349.

 

  1. Factors influencing nucleo-cytoplasmic trafficking: which matter? Response to Alvisi & Jans' comment on Phosphorylation adjacent to the nuclear localization signal of human dUTPase abolishes nuclear import: structural and mechanistic insights. G. Róna, M. Borsos, B. Kobe and B. G. Vértessy. Acta Cryst., October 2014, D70, Part 10, pp 2777-2778.

 

  1. NLS copy-number variation governs efficiency of nuclear import – case study on dUTPases. Gergely Róna, Hajnalka L. Pálinkás, Máté Borsos, András Horváth, Ildikó Scheer, András Benedek, Gergely N. Nagy, Imre Zagyva and Beáta G. Vértessy. FEBS (2014).

 

  1. A cool hybrid approach to the herpesvirus ‘life’ cycle. Tzviya Zeev-Ben-Mordehai, Christoph Hagen, Kay Grünewald. Current Opinion in Virology, April 2014, Vol 5, pp 42-49.

 

  1. Highly potent dUTPase inhibition by a bacterial repressor protein reveals a novel mechanism for gene expression control. Judit E. Szabó, Veronika Németh, Veronika Papp-Kádár, Kinga Nyíri, Ibolya Leveles, Ábris Á. Bendes, Imre Zagyva, Gergely Róna, Hajnalka L. Pálinkás, Balázs Besztercei, Olivér Ozohanics, Károly Vékey, Károly Liliom, Judit Tóth and Beáta G. Vértessy. Nucl. Acids Res., October 2014, 42 (19), pp 11912-11920.

 

  1. dxtbx: the diffraction experiment toolbox. J. M. Parkhurst, A. S. Brewster, L. Fuentes-Montero, D. G. Waterman, J. Hattne, A. W. Ashton, N. Echols, G. Evans, N. K. Sauter and G. Winter. J. Appl. Cryst. (2014), 47, Part 4, pp 1459-1465.

 

  1. The structure of a PII signaling protein from a halophilic archaeon reveals novel traits and high-salt adaptations. Carles Palanca, Laia Pedro-Roig, José Luis Llácer, Mónica Camacho, María J. Bonete and Vicente Rubio. FEBS, August 2014, Vol 281, Issue 15, pp 3299-3314.

 

  1. Novel thermosensitive telechelic PEGs with antioxidant activity: synthesis, molecular properties and conformational behaviour. Olga Sergeeva, Petr S. Vlasov, Nina S. Domnina, Anna Bogomolova, Petr V. Konarev, Dmitri I. Svergun, Zuzana Walterova, Jiri Horsky, Petr Stepanek and Sergey K. Filippov. RSC Adv. (2014), 4, pp 41763-41771.

 

  1. SASBDB, a repository for biological small-angle scattering data. Erica Valentini, Alexey G. Kikhney, Gianpietro Previtali, Cy M. Jeffries and Dmitri I. Svergun. Nucl. Acids Res. (2014).

 

  1. Endophilin-A1 BAR domain interaction with arachidonyl CoA. Maxim V. Petoukhov, Winfried Weissenhorn and Dmitri I. Svergun. Front. Mol. Biosci., October 2014.

 

  1. Crystal Structure of Bombyx mori Lipoprotein 6: Comparative Structural Analysis of the 30-kDa Lipoprotein Family. Agnieszka J. Pietrzyk, Anna Bujacz, Malgorzata Łochynska, Mariusz Jaskolski, Grzegorz Bujacz. PLOS One, November 2014.

 

  1. Identification of Phe187 as a Crucial Dimerization Determinant Facilitates Crystallization of a Monomeric Retroviral Integrase Core Domain. M. Galilee, A. Alian. Structure, October 2014, Vol 22, Issue 10, pp 1512-1519.

 

  1. The Metagenomic Telescope. B. Szalkai, I. Scheer, K. Nagy, B.G. Vertessy, V. Grolmusz. PLOS One, July 2014.

 

  1. Crystal structure of the lytic CHAPK domain of the endolysin LysK from Staphylococcus aureus bacteriophage K. Marta Sanz-Gaitero, Ruth Keary, Carmela Garcia-Doval, Aidan Coffey and Mark J. van Raaij. Virology Journal (2014), Vol 11.

 

  1. Designing a Multimer Allergen for Diagnosis and Immunotherapy of Dog Allergic Patients. Ola B. Nilsson, Theresa Neimert-Andersson, Mattias Bronge, Jeanette Grundström, Ranjana Sarma, Hannes Uchtenhagen, Alexey Kikhney, Tatyana Sandalova, Erik Holmgren, Dmitri Svergun, Adnane Achour, Marianne van Hage, Hans Grönlund. PLOS One (2014).

 

  1. Cloning, purification and preliminary crystallographic analysis of Ara127N, a GH127 β-L-arabinofuranosidase from Geobacillus stearothermophilus T6. Shifra Lansky, Rachel Salama, Roie Dann, Izhak Shner, Babu A. Manjasetty, Hassan Belrhali, Yuval Shohamb and Gil Shoham. Acta Cryst., August 2014, F70, Part 8, pp 1038-1045.

 

  1. Preventive DNA repair by sanitizing the cellular (deoxy) nucleoside triphosphate pool. Gergely N. Nagy, Ibolya Leveles, Beáta G. Vértessy. FEBS Journal, (2014) Vol 281, Issue 18, pp 4207-4223.

 

  1. A β1-6/β1-3 galactosidase from Bifidobacterium animalis subsp. lactis Bl-04 gives insight into sub-specificities of β-galactoside catabolism within Bifidobacterium. Alexander Holm Viborg, Folmer Fredslund, Takane Katayama, Stinne Kirketerp Nielsen, Birte Svensson, Motomitsu Kitaoka, Leila Lo Leggio and Maher Abou Hachem. Molecular Microbiology (2014).

 

  1. Crystal structure of the vitamin B3 transporter PnuC, a full-length SWEET homolog. M. Jaehme, A. Guskov, D. J. Slotboom. Nature Structural & Molecular Biology, 2014, Vol 21, pp 1013-1015.

 

  1. Structure and function study of the complex that synthesizes S-adenosylmethionine. Ben Murray, Svetlana V. Antonyuk, Alberto Marina, Sebastiaan M. Van Liempd, Shelly C. Lu, Jose M. Mato, S. Samar Hasnain and Adriana L. Rojas. IUCrJ, Vol 1, Part 4, July 2014, pp 240-249.

 

  1. New methods for indexing multi-lattice diffraction data. R. J. Gildea, D. G. Waterman, J. M. Parkhurst, D. Axford, G. Sutton, D. I. Stuart, N. K. Sauter, G. Evans and G. Winter. Acta Cryst., D70, Part 10, October 2014, pp 2652-2666.

 

  1. Lysosome sorting of β-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor.  Yuguang Zhao, Jingshan Ren, Sergi Padilla-Parra, Elizabeth E. Fry & David I. Stuart. Nature Communications, 5, Article no. 4321, 2014.

 

  1. Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines. Vanessa Parmenopoulou, Anastassia L. Kantsadi, Vicky G. Tsirkone, Demetra S.M. Chatzileontiadou, Stella Manta, Spyros E. Zographos, Christina Molfeta, Georgios Archontis, Loranne Agius, Joseph M. Hayes, Demetres D. Leonidas, Dimitri Komiotis. Bioorganic & Medicinal Chemistry, Vol 22, Issue 17, September 2014, pp 4810-4825.

 

  1. Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase. Rajaram Venkatesan, Shiv K. Sah-Teli, Luqman O. Awoniyi, Guangyu Jiang, Piotr Prus, Alexander J. Kastaniotis, J. Kalervo Hiltunen, Rik K. Wierenga & Zhijun Chen. Nature Communications, 5, Article no. 4805, 2014.

 

  1. The crystal structure of archaeal serine hydroxymethyltransferase reveals idiosyncratic features likely required to withstand high temperatures. Francesco Angelucci, Veronica Morea, Sebastiana Angelaccio, Fulvio Saccoccia, Roberto Contestabile and Andrea Ilari. Proteins, Vol 82, Issue 12, December 2014, pp 3437-3449.

 

  1. Crystal structures of free and antagonist-bound states of human ​α9 nicotinic receptor extracellular domain. Marios Zouridakis, Petros Giastas, Eleftherios Zarkadas, Dafni Chroni-Tzartou, Piotr Bregestovski & Socrates J. Tzartos. Nature Structural & Molecular Biology, 21, 2014, pp 976-980.

 

  1. The CD27L and CTP1L Endolysins Targeting Clostridia Contain a Built-in Trigger and Release Factor. Matthew Dunne, Haydyn D. T. Mertens, Vasiliki Garefalaki, Cy M. Jeffries, Andrew Thompson, Edward A. Lemke, Dmitri I. Svergun, Melinda J. Mayer, Arjan Narbad, Rob Meijers. PLOS Pathogens, 2014.

 

  1. The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold. Tim Schulte, Jonas Löfling, Cecilia Mikaelsson, Alexey Kikhney, Karina Hentrich, Aurora Diamante, Christine Ebel, Staffan Normark, Dmitri Svergun, Birgitta Henriques-Normark and and Adnane Achour. Open Biology, 4, 2014.

 

  1. Crystal structures and functional studies clarify substrate selectivity and catalytic residues for the unique orphan enzyme N-acetyl-D-mannosamine dehydrogenase. Agustín Sola‑Carvajal, Fernando Gil‑Ortiz, Francisco García‑Carmona, Vicente Rubio and Álvaro Sánchez‑Ferrer. Biochemical Journal, Vol 462, Number 3, 2014, pp 499-511.

 

  1. Glucopyranosylidene-spiro-iminothiazolidinone, a new bicyclic ring system: Synthesis, derivatization, and evaluation for inhibition of glycogen phosphorylase by enzyme kinetic and crystallographic methods. Katalin Czifrák, András Páhi, Szabina Deák, Attila Kiss-Szikszai, Katalin E. Kövér, Tibor Docsa, Pál Gergely, Kyra-Melinda Alexacou, Maria Papakonstantinou, Demetres D. Leonidas, Spyros E. Zographos, Evangelia D. Chrysina, László Somsák. Bioorganic & Medicinal Chemistry, Vol 22, Issue 15, August 2014, pp 4028-4041.

 

  1. A conformational switch in collybistin determines the differentiation of inhibitory postsynapses. Tolga Soykan, Daniela Schneeberger, Giancarlo Tria, Claudia Buechner, Nicole Bader, Dmitri Svergun, Ingrid Tessmer, Alexandros Poulopoulos, Theofilos Papadopoulos, Frédérique Varoqueaux, Hermann Schindelin and Nils Brose. The EMBO Journal, Vol 33, Issue 18, September 2014, pp 2113-2133.

 

  1. Engineering the internal cavity of neuroglobin demonstrates the role of the haem-sliding mechanism. G. Avella, C. Ardiccioni, A. Scaglione, T. Moschetti, C. Rondinelli, L. C. Montemiglio, C. Savino, A. Giuffrè, M. Brunori and B. Vallone. Acta Cryst., D70, 2014, pp 1640-1648.

 

  1. Structural Basis for the Oligomerization of the MADS Domain Transcription Factor SEPALLATA3 in Arabidopsis. Sriharsha Puranik, Samira Acajjaoui, Simon Conn, Luca Costa, Vanessa Conn, Anthony Vial, Romain Marcellin, Rainer Melzer, Elizabeth Brown, Darren Hart, Günter Theißen, Catarina S. Silva, François Parcy, Renaud Dumas, Max Nanao and Chloe Zubieta. The Plant Cell, Vol 26, No. 9, September 2014, pp 3603-3615.

 

  1. Loop Electrostatics Modulates the Intersubunit Interactions in Ferritin. Caterina Bernacchioni, Veronica Ghini, Cecilia Pozzi, Flavio Di Pisa, Elizabeth C. Theil and Paola Turano. ACS Chem. Biol., 2014, 9 (11), pp 2517-2525.

 

  1. Dynamics of re-constitution of the human nuclear proteome after cell division is regulated by NLS-adjacent phosphorylation. Gergely Róna, Máté Borsos, Jonathan J. Ellis, Ahmed M. Mehdi, Mary Christie, Zsuzsanna Környei, Máté Neubrandt, Judit Tóth, Zoltán Bozóky, László Buday, Emília Madarász, Mikael Bodén, Bostjan Kobe & Beáta G. Vértessy. Cell Cycle, 2014.

 

  1. Specific binding of gibberellic acid by Cytokinin-Specific Binding Proteins: a new aspect of plant hormone-binding proteins with the PR-10 fold. M. Ruszkowski, J. Sliwiak, A. Ciesielska, J. Barciszewski, M. Sikorski and M. Jaskolski. Acta Cryst. D70, Part 7, July 2014, pp 2032-2041.

 

  1. Structure-specificity relationships in Abp, a GH27 β-L-arabinopyranosidase from Geobacillus stearothermophilus T6. S. Lansky, R. Salama, H. V. Solomon, H. Feinberg, H. Belrhali, Y. Shoham and G. Shoham. Acta Cryst., D70, Part 11, November 2014, pp 2994-3012.

 

  1. Structure and Function of a Decarboxylating Agrobacterium tumefaciens Keto-deoxy-d-galactarate Dehydratase. H. Taberman, M. Andberg, T. Parkkinen, J. Jänis, M. Penttilä, N. Hakulinen, A. Koivula, and J. Rouvinen. Biochemistry, 2014, 53 (51), pp 8052–8060.

 

  1. Crystal Structure of Bombyx mori Lipoprotein 6: Comparative Structural Analysis of the 30-kDa Lipoprotein Family. A. J. Pietrzyk, A. Bujacz, M. Łochynska, M. Jaskolski and G. Bujacz. (2014) PLoS ONE 9(11): e108761. doi: 10.1371/journal.pone.0108761.

 

  1. The soft x-ray transform. J. Klukowska, G.T. Herman, J. Otón, R. Marabini and JM Carazo. (2014) Inverse Problems 30 125015.

 

  1. Cryo-Soft X-ray Tomography of the Cell. E. Pereiro and F.J. Chichón. 2014. eLS

 

  1. Impact of residues remote from the catalytic centre on enzyme catalysis of ​copper nitrite reductase. Nicole G. H. Leferink, Svetlana V. Antonyuk, Joseline A. Houwman,    Nigel S. Scrutton, Robert R. Eady and S. Samar Hasnain. 2014. Nature Communications 5, Article number:4395.

 

  1. The Olfactomedin Domain from Gliomedin is a β-Propeller with Unique Structural Properties. Huijong Han and Petri Kursula. J Biol Chem. 2015 Feb 6;290(6)., pp 3612-21.

 

  1. Preliminary crystallographic analysis of Xyn52B2, a GH52 ß-D-xylosidase from Geobacillus stearothermophilus T6. R. Dann, S. Lansky, N. Lavid, A. Zehavi, V. Belakhov, T. Baasov, H. Dvir, B. Manjasetty, H. Belrhali, Y. Shoham and G. Shoham. Acta Cryst. (2014). F70, pp 1675-1682.

 

  1. Structure based inhibitor design targeting glycogen phosphorylase b. Virtual screening, synthesis, biochemical and biological assessment of novel N-acyl-β-d-glucopyranosylamines. Vanessa Parmenopoulou, Anastassia L. Kantsadi, Vicky G. Tsirkone, Demetra S.M. Chatzileontiadou, Stella Manta, Spyros E. Zographos, Christina Molfeta, Georgios Archontis, Loranne Agius, Joseph M. Hayes, Demetres D. Leonidas and Dimitri Komiotis.Bioorganic & Medicinal Chemistry, Volume 22, Issue 17, 1 September 2014, Pages 4810-4825.

 

  1. The crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase (T1): insight into the reaction mechanism of its thiolase and thioesterase activities. T.-R. Kiema, R. K. Harijan, M. Strozyk, T. Fukao, S. E. H. Alexson and R. K. Wierenga. Acta Cryst. (2014). D70, pp 3212-3225.

 
 

  1. Structure of the hexameric ​HerA ATPase reveals a mechanism of translocation-coupled DNA-end processing in archaea. Neil J. Rzechorzek, John K. Blackwood, Sian M. Bray, Joseph D. Maman, Luca Pellegrini and Nicholas P. Robinson. Nature Communications 5, Article number: 5506, 2014.

 

  1. Glucopyranosylidene-spiro-iminothiazolidinone, a new bicyclic ring system: Synthesis, derivatization, and evaluation for inhibition of glycogen phosphorylase by enzyme kinetic and crystallographic methods. Katalin Czifrák, András Páhi, Szabina Deák, Attila Kiss-Szikszai, Katalin E. Kövérb, Tibor Docsa, Pál Gergely, Kyra-Melinda Alexacou, Maria Papakonstantinou, Demetres D. Leonidas, Spyros E. Zographos, Evangelia D. Chrysina and László Somsák. Bioorganic & Medicinal Chemistry, Volume 22, Issue 15, 1 August 2014, pp 4028–4041.

 

  1. The Structure and Regulation of Human Muscle α-Actinin. Euripedes de Almeida Ribeiro Jr., Nikos Pinotsis, Andrea Ghisleni, Anita Salmazo, Petr V. Konarev, Julius Kostan, Björn Sjöblom, Claudia Schreiner, Anton A. Polyansky, Eirini A. Gkougkoulia, Mark R. Holt, Finn L. Aachmann, Bojan Žagrović, Enrica Bordignon, Katharina F. Pirker, Dmitri I. Svergun, Mathias Gautel and Kristina Djinović-Carugo. Cell, Volume 159, Issue 6, 4 December 2014, pp 1447–1460.

 

  1. Indolo-Phakellins as β5-Specific Noncovalent Proteasome Inhibitors. Dr. Philipp Beck1, Theresa A. Lansdell2, Nicole M. Hewlett2, Prof. Dr. Jetze J. Tepe2,* andProf. Dr. Michael Groll1,Angewandte Chemie International Edition, Volume 54, Issue 9, February 23, 2015. pp 2830–2833.

 

  1. Detection of Tumor-Associated Glycopeptides by Lectins: The Peptide Context Modulates Carbohydrate Recognition. David Madariaga, Nuria Martínez-Sáez, Víctor J. Somovilla, Helena Coelho, Jessika Valero-González, Jorge Castro-López, Juan L. Asensio, Jesús Jiménez-Barbero, Jesús H. Busto, Alberto Avenoza, Filipa Marcelo, Ramón Hurtado-Guerrero, Francisco Corzana and Jesús M. Peregrina. ACS Chem. Biol., 2015, 10 (3), pp 747–756.

 

  1. Crystallization and preliminary crystallographic studies of a novel noncatalytic carbohydrate-binding module from the Ruminococcus flavefaciens cellulosome. I. Venditto, A. Goyal, A. Thompson, L. M. A. Ferreira, C. M. G. A. Fontes and S. Najmudin. Acta Cryst. (2015). F71, pp 45-48.

 

  1. Data Analysis WorkbeNch (DAWN). M. Basham, J. Filik, M. T. Wharmby, P. C. Y. Chang, B. El Kassaby, M. Gerring, J. Aishima, K. Levik, B. C. A. Pulford, I. Sikharulidze, D. Sneddon, M. Webber, S. S. Dhesi, F. Maccherozzi, O. Svensson, S. Brockhauser, G. Náray and A. W. Ashton.J. Synchrotron Rad. (2015). Volume 22, Part 3.

 

  1. Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1. Michael J. Capper, Paul M. O’Neill, Nicholas Fisher, Richard W. Strange, Darren Moss, Stephen A. Ward, Neil G. Berry, Alexandre S. Lawrenson, S. Samar Hasnain, Giancarlo A. Biagini and Svetlana V. Antonyuk. PNAS, vol. 112 no. 3, 2015, pp 755-760.

 

  1. Crystallization of two operator complexes from the Vibrio cholerae HigBA2 toxin-antitoxin module. S. Hadzi, A. Garcia-Pino, K. Gerdes, J. Lah and R. Loris. Acta Cryst. (2015). F71, pp 226-233.

 

  1. A small and robust active beamstop for scattering experiments on high-brilliance undulator beamlines. C. E. Blanchet, C. Hermes, D. I. Svergun and S. Fiedler. J. Synchrotron Rad. (2015). 22, pp 461-464.

 

  1. ISPyB for BioSAXS, the gateway to user autonomy in solution scattering experiments. A. De Maria Antolinos, P. Pernot, M. E. Brennich, J. Kieffer, M. W. Bowler, S. Delageniere, S. Ohlsson, S. Malbet Monaco, A. Ashton, D. Franke, D. Svergun, S. McSweeney, E. Gordon and A. Round.Acta Cryst. (2015). D71, pp 76-85.

 

  1. Correlation Map, a goodness-of-fit test for one-dimensional X-ray scattering spectra. Daniel Franke, Cy M Jeffries and Dmitri I Svergun. Nature Methods (2015).

 

  1. Measurement of the modulation transfer function of an X-ray microscope based on multiple Fourier orders analysis of a Siemens star. Joaquín Otón, Carlos Oscar S. Sorzano, Roberto Marabini, Eva Pereiro, and Jose M. Carazo. Optics Express, Vol. 23, Issue 8, pp. 9567-9572 (2015).

 

  1. Human Δ3,Δ2-enoyl-CoA isomerase, type 2: a structural enzymology study on the catalytic role of its ACBP domain and helix-10. Goodluck U. Onwukwe, Petri Kursula, M. Kristian Koski, Werner Schmitz and Rik K. Wierenga. FEBS Journal, Volume 282, Issue 4, pp 746–768, 2015.

 

  1. Hen Egg-White Lysozyme Crystallisation: Protein Stacking and Structure Stability Enhanced by a Tellurium(VI)-Centred Polyoxotungstate. Aleksandar Bijelic, Christian Molitor, Dr. Stephan G. Mauracher, Dr. Rami Al-Oweini, Prof. Dr. Ulrich Kortz and Annette Rompel. ChemBioChemVolume 16, Issue 2, 2015., pp 233–241.

 

  1. Structure of Human N-Acylphosphatidylethanolamine-Hydrolyzing Phospholipase D: Regulation of Fatty Acid Ethanolamide Biosynthesis by Bile Acids. Paola Magotti, Inga Bauer, Miki Igarashi, Masih Babagoli, Roberto Marotta, Daniele Piomelli and Gianpiero Garau. Structure, Volume 23, Issue 3, 3 March 2015, pp 598–604.

 

  1. Structure-Based Design of Potent Small-Molecule Binders to the S-Component of the ECF Transporter for Thiamine. Lotteke J. Y. M. Swier, Leticia Monjas, Dr. Albert Guskov, Alrik R. de Voogd, Dr. Guus B. Erkens, Prof. Dirk J. Slotboom and Dr. Anna K. H. Hirsch. ChemBioChem, Volume 16, Issue 5, 2015., pp 819–826.

 

  1. Catalytic features and crystal structure of a tau class glutathione transferase from Glycine max specifically upregulated in response to soybean mosaic virus infections. Katholiki Skopelitou, Abdi W. Muleta, Anastassios C. Papageorgiou, Evangelia Chronopoulou and Nikolaos E. Labrou. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Volume 1854, Issue 2, February 2015, pp 166-177.

 

  1. Two putative polysaccharide deacetylases are required for osmotic stability and cell shape maintenance in Bacillus anthracis. Sofia Arnaouteli, Petros Giastas, Athina Andreou, Mary Tzanodaskalaki, Christine Aldridge, Socrates J. Tzartos, Waldemar Vollmer, Elias Eliopoulos3 and Vassilis Bouriotis. J Biol Chem., 2015 Mar 30.

 

  1. Advanced ensemble modelling of flexible macromolecules using X-ray solution scattering. Giancarlo Tria, Haydyn D. T. Mertens, Michael Kachala and Dmitri I. Svergun. IUCrJ, Volume 2, Part 2, March 2015, pp 207-217.

 

  1. A new dehydratase conferring innate resistance to thiacetazone and intra-amoebal survival of Mycobacterium smegmatis. Séverine Carrère-Kremer, Mickael Blaise, Vipul K. Singh, Laeticia Alibaud, Edouard Tuaillon, Iman Halloum, Robert van de Weerd, Yann Guérardel, Michel Drancourt, Howard Takiff, Jeroen Geurtsen and Laurent Kremer. Mol Microbiol. 2015 Mar 9. doi: 10.1111/mmi.12992.

 

  1. Limiting radiation damage for high-brilliance biological solution scattering: practical experience at the EMBL P12 beamline PETRAIII. C. M. Jeffries, M. A. Graewert, D. I. Svergun and C. E. Blanchet. J. Synchrotron Rad. (2015). 22, pp 273-279.

 

  1. Molecular Basis of Histone Tail Recognition by Human TIP5 PHD Finger and Bromodomain of the Chromatin Remodeling Complex NoRC. Cynthia Tallant, Erica Valentini, Oleg Fedorov, Lois Overvoorde, Fleur M. Ferguson, Panagis Filippakopoulos, Dmitri I. Svergun, Stefan Knapp and Alessio Ciulli. Structure, Volume 23, Issue 1, 2015, pp 80-92.

 

  1. Cross-species inhibition of dUTPase via the Staphylococcal Stl protein perturbs dNTP pool and colony formation in Mycobacterium. Rita Hirmondó, Judit E. Szabó, Kinga Nyíri, Szilvia Tarjányi, Paula Dobrotka, Judit Tóth and Beáta G. Vértessy. DNA Repair, Volume 30, June 2015, pp 21-27.

 

  1. The substrate -free and -bound crystal structures of the duplicated taurocyamine kinase from the human parasite Schistosoma mansoni. Romain Merceron1, Ayman M. Awama2, Roland Montserret3, Olivier Marcillat2 and Patrice Gouet. J Biol Chem. 2015 Apr 2. pii: jbc.M114.628909.

 

  1. Structural basis for the interaction of protein S1 with the Escherichia coli ribosome. Konstantin Byrgazov, Irina Grishkovskaya, Stefan Arenz, Nicolas Coudevylle, Hannes Temmel, Daniel N. Wilson, Kristina Djinovic-Carugo and Isabella Moll. Nucl. Acids Res. (January 2015) 43 (1): pp 661-673.

 

  1. BioSAXS Sample Changer: a robotic sample changer for rapid and reliable high-throughput X-ray solution scattering experiments. A. Round, F. Felisaz, L. Fodinger, A. Gobbo, J. Huet, C. Villard, C. E. Blanchet, P. Pernot, S. McSweeney, M. Roessle, D. I. Svergun and F. Cipriani. Acta Cryst. (2015). D71, pp 67-75.

 

  1. Bortezomib-Resistant Mutant Proteasomes: Structural and Biochemical Evaluation with Carfilzomib and ONX 0914. Eva M. Huber, Wolfgang Heinemeyer and Michael Groll. Structure, Volume 23, Issuee2, February 2015, pp 407-417.

 

  1. High-resolution crystal structure of a polyextreme GH43 glycosidase from Halothermothrix orenii with α-L-arabinofuranosidase activity. N. Hassan, L. D. Kori, R. Gandini, B. K. C. Patel, C. Divne and T. C. Tan. Acta Cryst. (2015). F71, pp 338-345.

 

  1. Structural Insights into Ca2+-Calmodulin Regulation of Plectin 1a-Integrin β4 Interaction in Hemidesmosomes. Jae-Geun Song, Julius Kostan, Friedel Drepper, Bettina Knapp, Euripedes de Almeida Ribeiro Jr., Petr V. Konarev, Irina Grishkovskaya, Gerhard Wiche, Martin Gregor, Dmitri I. Svergun, Bettina Warscheid and Kristina Djinović-Carugo. Structure, Volume 23, Issue 3, March 2015, pp 558-570.

 

  1. Cell-surface attachment of bacterial multi-enzyme complexes involves highly dynamic protein-protein anchors. Kate Cameron, Shabir Najmudin, Victor D. Alves, Edward A. Bayer, Steven P. Smith, Pedro Bule, Helen Waller, Luis M. A. Ferreira, Harry J. Gilbert and Carlos M. G. A. Fontes.J Biol Chem. 2015 Apr 8. pii: jbc.M114.633339.

 

  1. Arc is a flexible modular protein capable of reversible self-oligomerization. Craig Myrum, Anne Baumann, Helene J. Bustad, Marte I. Flydal, Vincent Mariaule, Sara Alvira, Jorge Cuéllar, Jan Haavik, Jonathan Soulé, José Maria Valpuesta, José Antonio Márquez, Aurora Martinez and Clive R. Bramham. Biochem. J. (2015) Immediate Publication, doi:10.1042/BJ20141446.

 

  1. dUTPase expression correlates with cell division potential in Drosophila melanogaster. András Horváth1, Júlia Batki, László Henn, Tamás Lukacsovich, Gergely Róna, Miklós Erdélyi and Beáta G. Vértessy. FEBS Journal, 2015.

 

  1. Versatile sample environments and automation for biological solution X-ray scattering experiments at the P12 beamline (PETRA III, DESY). C. E. Blanchet, A. Spilotros, F. Schwemmer, M. A. Graewert, A. Kikhney, C. M. Jeffries, D. Franke, D. Mark, R. Zengerle, F. Cipriani, S. Fiedler, M. Roessle and D. I. Svergun. J. Appl. Cryst. (2015). 48, pp 431-443.

 

  1. Structure and boosting activity of a starch-degrading lytic polysaccharide monooxygenase. Leila Lo Leggio, Thomas J. Simmons, Jens-Christian N. Poulsen, Kristian E. H. Frandsen, Glyn R. Hemsworth, Mary A. Stringer, Pernille von Freiesleben, Morten Tovborg, Katja S. Johansen, Leonardo De Maria, Paul V. Harris, Chee-Leong Soong, Paul Dupree, Theodora Tryfona,    Nicolas Lenfant, Bernard Henrissat, Gideon J. Davies and Paul H. Walton. Nature Communications 6, Article number:5961, 2015.

 

  1. One-Step Purification and Porin Transport Activity of the Major Outer Membrane Proteins P2 from Haemophilus influenzae, FomA from Fusobacterium nucleatum and PorB from Neisseria meningitidis. Christof Kattner, Sabrina Pfennig, Paola Massari and Mikio Tanabe. Applied Biochemistry and Biotechnology, March 2015, Volume 175, Issue 6, pp 2907-2915.

 

  1. An intermolecular binding mechanism involving multiple LysM domains mediates carbohydrate recognition by an endopeptidase. J. E. M. M. Wong, S. R. Midtgaard, K. Gysel, M. B. Thygesen, K. K. Sørensen, K. J. Jensen, J. Stougaard, S. Thirup and M. Blaise. Acta Cryst. (2015). D71, pp 592-605.

 

  1. Mutations decouple proton transfer from phosphate cleavage in the dUTPase catalytic reaction. Anna Lopata , Pablo G. Jambrina , Pankaz K. Sharma , Bernard R. Brooks , Judit Toth , Beata G. Vertessy , and Edina Rosta. ACS Catal., April 2015., DOI: 10.1021/cs502087f.

 

  1. Four crystal structures of human LLT1, a ligand of human NKR-P1, in varied glycosylation and oligomerization states. T. Skálová, J. Bláha, K. Harlos, J. Dusková, T. Koval', J. Stránský, J. Hasek, O. Vanek and J. Dohnálek. Acta Cryst. (2015). D71, pp 578-591.

 

  1. Structural Basis of Functional Diversification of the HD-GYP Domain Revealed by the Pseudomonas aeruginosa PA4781 Protein, Which Displays an Unselective Bimetallic Binding Site. Serena Rinaldo, Alessandro Paiardini, Valentina Stelitano, Paolo Brunotti, Laura Cervoni, Silvia Fernicola, Carmela Protano, Matteo Vitali, Francesca Cutruzzolà and Giorgio Giardina. J. Bacteriol., April 2015., vol. 197 no. 8, pp 1525-1535.

 

  1. Combination of X-ray crystallography, SAXS and DEER to obtain the structure of the FnIII-3,4 domains of integrin α6β4. N. Alonso-García, I. García-Rubio, J. A. Manso, R. M. Buey, H. Urien, A. Sonnenberg, G. Jeschke and J. M. de Pereda. Acta Cryst. (2015). D71, pp 969-985.

 

  1. Hidden disorder propensity of the N-terminal segment of universal adapter protein 14-3-3 is manifested in its monomeric form: Novel insights into protein dimerization and multifunctionality. Nikolai N. Sluchankoa and Vladimir N. Uverskyb.Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Volume 1854, Issue 5, May 2015, pp 492–504.

 

  1. Structure of ​p15PAF–​PCNA complex and implications for clamp sliding during DNA replication and repair. Alfredo De Biasio, Alain Ibáñez de Opakua, Gulnahar B. Mortuza, Rafael Molina, Tiago N. Cordeiro, Francisco Castillo, Maider Villate, Nekane Merino, Sandra Delgado, David Gil-Cartón, Irene Luque, Tammo Diercks, Pau Bernadó, Guillermo Montoya and Francisco J. Blanco. Nature Communications 6, Article number:6439, doi:10.1038/ncomms7439.

 

  1. Structure of γ-conglutin: insight into the quaternary structure of 7S basic globulins from legumes. Jaroslaw Czubinski, Jakub Barciszewski, Miroslaw Gilski, Kamil Szpotkowski, Janusz Debski, Eleonora Lampart-Szczapa and Mariusz Jaskolski. Biological Crystallography, Volume 71, Part 2, pp 224-238, February 2015.

 

  1. The Mechanism of Color Change in the Neon Tetra Fish: a Light-Induced Tunable Photonic Crystal Array. Dvir Gur, Benjamin A. Palmer, Ben Leshem, Dan Oron, Peter Fratzl, Steve Weiner and Lia Addadi. (2015) Angew. Chem. Int. Ed.. doi: 10.1002/anie.201502268

 

  1. Erratum to: Aromatic aldehydes at the active site of aldehyde oxidoreductase from Desulfovibrio gigas : reactivity and molecular details of the enzyme–substrate and enzyme–product interaction. Hugo D. Correia, Jacopo Marangon, Carlos D. Brondino, Jose J. G. Moura, Maria J. Romão, Pablo J. González and Teresa Santos-Silva. JBIC, March 2015, Volume 20, Issue 2, pp 231.

 

  1. Engineering a nickase on the homing endonuclease I-DmoI scaffold. Rafael Molina, María José Marcaida, Pilar Redondo, Marco Marenchino, Philippe Duchateau, Marco D'Abramo, Guillermo Montoya and Jesús Prieto. 2015., JBC, doi: 10.1074/jbc.M115.658666.

 

  1. Molecular Mechanism for the Thermo-Sensitive Phenotype of CHO-MT58 Cell Line Harbouring a Mutant CTP:Phosphocholine Cytidylyltransferase.
    Lívia Marton, Gergely N. Nagy, Olivér Ozohanics, Anikó Lábas, Balázs Krámos, Julianna Oláh, Károly Vékey and Beáta G. Vértessy. PLoS ONE 10(6): e0129632. doi:10.1371/journal.pone.0129632., (2015).

 

  1. The Carboxy-Terminal Domain of Erb1 Is a Seven-Bladed ß-Propeller that Binds RNA. Wegrecki Marcin, Jose Luis Neira and Jeronimo Bravo. (2015) PLoS ONE 10(5): e0128164. doi: 10.1371/journal.pone.0128164

 

  1. Structure of the nuclease subunit of human mitochondrial RNase P. Linda Reinhard, Sagar Sridhara and B. Martin Halberg. Nucl. Acids Res. (2015) doi: 10.1093/nar/gkv481.

 

  1. Pharmacophore-Based Virtual Screening to Discover New Active Compounds for Human Choline Kinase α1. Lucía Serrán-Aguilera, Roberto Nuti, Luisa C. López-Cara, Miguel Á. Gallo Mezo, Antonio Macchiarulo, Antonio Entrena and Ramón Hurtado-Guerrero. Molecular Informatics, Special Issue: 20th EuroQSAR: Understanding Chemical-Biological Interactions., Vol 34, Issue 6-7, pp 458–466, June 2015.

 

  1. Family 46 Carbohydrate-binding Modules Contribute to the Enzymatic Hydrolysis of Xyloglucan and β-1,3–1,4-Glucans through Distinct Mechanisms. Immacolata Venditto, Shabir Najmudin, Ana S. Luís, Luís M. A. Ferreira, Kazuo Sakka, J. Paul Knox‖, Harry J. Gilbert and Carlos M. G. A. Fontes. JBC, 290, April 24 2015., pp 10572 - 10586.

 

  1. Automated Pipeline for Purification, Biophysical and X-Ray Analysis of Biomacromolecular Solutions. Melissa A. Graewert, Daniel Franke, Cy M. Jeffries, Clement E. Blanchet, Darja Ruskule, Katja Kuhle, Antje Flieger, Bernd Schäfer, Bernd Tartsch, Rob Meijers & Dmitri I. Svergun. Scientific Reports 5, (2015)., Article number:10734, doi:10.1038/srep10734

 

  1. Polyproteins in structural biology. Thibaut Crépin, Christopher Swale, Alexandre Monod, Frederic Garzoni, Maxime Chaillet and Imre Berger. Curr. Opin. Struct. Biol., Vol 23, June 2013, pp 139-146.

 

  1. The Olfactomedin Domain from Gliomedin Is a β-Propeller with Unique Structural Properties. Huijong Han and Petri Kursula. JBC, 290, February 6, 2015., pp 3612-3621.

 

  1. Angelucci, Francesco, Bellelli, Andrea, Ardini, Matteo, Ippoliti, Rodolfo, Saccoccia, Fulvio and Morea, Veronica. (2015), One ring (or two) to hold them all – on the structure and function of protein nanotubes. FEBS Journal. doi: 10.1111/febs.13336.

 

  1. High-resolution crystal structure of the leucine-rich repeat domain of the human tumour suppressor PP32A (ANP32A). S. Zamora-Caballero, L. Siauciunaite-Gaubard and J. Bravo.Acta Cryst. (2015). F71, pp 684-687.

 

  1. Joaquín Otón, Carlos Oscar S. Sorzano, Roberto Marabini, Eva Pereiro, and Jose M. Carazo, "Measurement of the modulation transfer function of an X-ray microscope based on multiple Fourier orders analysis of a Siemens star," Opt. Express 23, (2015), pp 9567-9572.

 

  1. A posteriori determination of the useful data range for small-angle scattering experiments on dilute monodisperse systems. Petr V. Konareva, and Dmitri I. Svergun. IUCrJ, Volume 2, Part 3, May 2015, pp 352-360.

 

  1. Structure-Based Design of Potent Small-Molecule Binders to the S-Component of the ECF Transporter for Thiamine. Lotteke J. Y. M. Swier, Leticia Monjas, Albert Guskov, Alrik R. de Voogd, Guus B. Erkens, Dirk J. Slotboom, and Anna K. H. Hirsch. ChemBioChem, Volume16, Issue 5, (2015), pp 819-826.

 

  1. The Substrate-free and -bound Crystal Structures of the Duplicated Taurocyamine Kinase from the Human Parasite Schistosoma mansoni. Romain Merceron, Ayman M. Awama, Roland Montserret, Olivier Marcillat and Patrice Gouet. JBC, May 15, 2015., 290, pp 12951-12963.

 

  1. Cell-surface Attachment of Bacterial Multienzyme Complexes Involves Highly Dynamic Protein-Protein Anchors. Kate Cameron, Shabir Najmudin, Victor D. Alves, Edward A. Bayer, Steven P. Smith, Pedro Bule, Helen Waller, Luís M. A. Ferreira, Harry J. Gilbert and Carlos M. G. A. Fontes. JBC, May 22, 2015., 290, pp 13578-13590.

 

  1. Natural flavonoids as antidiabetic agents. The binding of gallic and ellagic acids to glycogen phosphorylase b. Efthimios Kyriakis, George A. Stravodimos, Anastassia L. Kantsadi, Demetra S.M. Chatzileontiadou, Vassiliki T. Skamnaki and Demetres D. Leonidas. FEBS Letters, Vol 589, Issue 15, July 2015, pp 1787-1794.

 

  1. Two Putative Polysaccharide Deacetylases Are Required for Osmotic Stability and Cell Shape Maintenance in Bacillus anthracis. Sofia Arnaouteli, Petros Giastas, Athina Andreou, Mary Tzanodaskalaki, Christine Aldridge, Socrates J. Tzartos, Waldemar Vollmer, Elias Eliopoulos and Vassilis Bouriotis. JBC, 290, May 2015, pp 13465-13478.

 

  1. Expression, purification, crystallization and preliminary X-ray analysis of CttA, a putative cellulose-binding protein from Ruminococcus flavefaciens. I. Venditto, P. Bule, A. Thompson, J. Sanchez-Weatherby, J. Sandy, L. M. A. Ferreira, C. M. G. A. Fontes and S. Najmudin. Acta Crystallographica Section F, Structural Biology Communications, Volume 71, Part 6 (June 2015)

 

  1. The N-terminal cytoplasmic domain of neuregulin 1 type III is intrinsically disordered.  Maryna Chukhlieb, Arne Raasakka, Salla Ruskamo and Petri Kursula. Amino Acids, May 2015, doi 10.1007/s00726-015-1998-x.

 

  1. Expression and purification of soluble and stable ectodomain of natural killer cell receptor LLT1 through high-density transfection of suspension adapted HEK293S GnTI− cells. Jan Bláha, Petr Pachl, Petr Novák and Ondřej Vaněka. Protein Expression and Purification, Volume 109, May 2015, pp 7–13., doi:10.1016/j.pep.2015.01.006.

 

  1. Encapsulation and Covalent Binding of Molecular Payload in Enzymatically Activated Micellar Nanocarriers. Ido Rosenbaum, Assaf J. Harnoy, Einat Tirosh, Marina Buzhor, Merav Segal, Liat Frid, Rona Shaharabani, Ram Avinery, Roy Beck and Roey J. Amir.J. Am. Chem. Soc., 2015, 137 (6), pp 2276–2284. DOI: 10.1021/ja510085s.

 

  1. Interaction of two imidazolium gemini surfactants with two model proteins BSA and HEWL. W. Gospodarczyk and M. Kozak. Colloid Polym Sci, July 2015, DOI:10.1007/s00396-015-3671-z.

 

  1. Combined crystal structure of a type-I cohesin, mutation and affinity-binding studies reveal structural determinants of cohesin-dockerin specificity. Kate Cameron, Jonathan Y. Weinstein, Olga Zhivin, Pedro Bule, Sarel J. Fleishman, Victor D. Alves, Harry J. Gilbert, Luís M.A. Ferreira, Carlos M.G.A. Fontes, Edward A. Bayer and Shabir Najmudin.JBC, May 2015,  doi: 10.1074/jbc.M115.653303.

 

  1. Expression, purification and crystallization of a family 55 [beta]-1,3-glucanase from Chaetomium thermophilum. A. C. Papageorgiou and D. Li. Acta Cryst. (2015)., F71, pp 680-683., doi:10.1107/S2053230X15006366.

 

  1. A high-affinity [18 F]-labeled phosphoramidate peptidomimetic PSMA-targeted inhibitor for PET imaging of prostate cancer. Tanushree Ganguly, Shorouk Dannoon, Mark R. Hopkins, Stephanie Murphy, Hendry Cahaya, Joseph E. Blecha, Salma Jivan, Christopher R. Drake, Cyril Barinka, Ella F. Jones, Henry F. VanBrocklin and Clifford E. Berkman. Nuclear Medicine and Biology, June 2015, doi:10.1016/j.nucmedbio.2015.06.003.

 

  1. The influence of novel gemini surfactants containing cycloalkyl side-chains on the structural phases of DNA in solution. Zuzanna Pietralik, Janet R. Kumita, Christopher M. Dobson and Maciej Kozak. Colloids and Surfaces B: Biointerfaces, Vol 131, July 2015, pp 83-92.

 

  1. The high-resolution crystal structure of phosphatidylinositol 4-kinase II[beta] and the crystal structure of phosphatidylinositol 4-kinase II[alpha] containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design. M. Klima, A. Baumlova, D. Chalupska, H. Hrebabecký, M. Dejmek, R. Nencka and E. Boura. Acta Cryst. (2015). D71, pp 1555-1563. doi:10.1107/S1399004715009505.

 

  1. The Crystal Structure and Small-Angle X-Ray Analysis of CsdL/TcdA Reveal a New tRNA Binding Motif in the MoeB/E1 Superfamily. Miguel López-Estepa, Ana Ardá, Martin Savko, Adam Round, William E. Shepard, Marta Bruix, Miquel Coll, Francisco J. Fernández, Jesús Jiménez-Barbero and M. Cristina Vega. PLoS One. 2015; 10(4): e0118606.

 

  1. Discovery of Potent and Selective Nonplanar Tankyrase Inhibiting Nicotinamide Mimics. Yves Nkizinkikoa, B.V.S. Suneel Kumar, Variam Ullas Jeankumar, Teemu Haikarainen, Jarkko Koivunen, Chanduri Madhuri, Perumal Yogeeswari, Harikanth Venkannagari, Ezeogo Obaji, Taina Pihlajaniemi, Dharmarajan Sriram aand Lari Lehtiö. Bioorganic & Medicinal Chemistry, July 2015. doi:10.1016/j.bmc.2015.06.063.

 

  1. Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation. Tien-Chye Tan, Daniel Kracher, Rosaria Gandini, Christoph Sygmund, Roman Kittl, Dietmar Haltrich, B. Martin Hällberg, Roland Ludwig and Christina Divne. Nature Communications 6, Article number:7542. July 2015, doi:10.1038/ncomms8542.

 

  1. Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation. Erandi Lira-Navarrete,    Matilde de las Rivas, Ismael Compañón, María Carmen Pallarés, Yun Kong, Javier Iglesias-Fernández, Gonçalo J. L. Bernardes, Jesús M. Peregrina, Carme Rovira, Pau Bernadó, Pierpaolo Bruscolini, Henrik Clausen, Anabel Lostao, Francisco Corzana and Ramon Hurtado-Guerrero. Nature Communications 6, Article number:6937, May 2015, doi:10.1038/ncomms7937.

 

  1. Structure of the hexameric HerA ATPase reveals a mechanism of translocation-coupled DNA-end processing in archaea. Neil J. Rzechorzek. John K. Blackwood, Sian M. Bray, Joseph D. Maman, Luca Pellegrini and Nicholas P. Robinson. Nat Commun 5: 5506., May 2015, doi:10.1038/ncomms6506.

 

  1. Structural bases for N-glycan processing by mannoside phosphorylase. S. Ladevèze, G. Cioci, P. Roblin, L. Mourey, S. Tranier and G. Potocki-Véronèse. Acta Cryst. (2015). D71, pp 1335-1346. doi:10.1107/S1399004715006604

 

  1. Structure of [gamma]-conglutin: insight into the quaternary structure of 7S basic globulins from legumes. J. Czubinski, J. Barciszewski, M. Gilski, K. Szpotkowski, J. Debski, E. Lampart-Szczapa and M. Jaskolski. Acta Cryst. (2015). D71, pp 224-238. doi:10.1107/S1399004714025073.

 

  1. New insights into the enzymatic mechanism of human chitotriosidase (CHIT1) catalytic domain by atomic resolution X-ray diffraction and hybrid QM/MM. Firas Fadel, Yuguang Zhao, Raul Cachau, Alexandra Cousido-Siah, Francesc X. Ruiz, Karl Harlos, Eduardo Howard, Andre Mitschler and Alberto Podjarny. Acta Cryst. (2015). D71, pp 1455-1470. doi:10.1107/S139900471500783X.

 

  1. Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro. Helen A. Paine, Amit Nathubhai, Esther C.Y. Woon, Peter T. Sunderland, Pauline J. Wood, Mary F. Mahon, Matthew D. Lloyd, Andrew S. Thompson, Teemu Haikarainen, Mohit Narwal, Lari Lehtiö and Michael D. Threadgill. Bioorganic & Medicinal Chemistry. July 2015, doi:10.1016/j.bmc.2015.06.061.

 

  1. Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases. Katerina Kumpan, Amit Nathubhai, Chenlu Zhang, b, Pauline J. Wood, Matthew D. Lloyda Andrew S. Thompson, Teemu Haikarainen, Lari Lehtiö and Michael D. Threadgill. Bioorganic & Medicinal Chemistry. July 2015, pp 3013-3032. doi:10.1016/j.bmc.2015.05.005.

 

  1. Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action. Ivana Mejdrova, Dominika Chalupská, Martin Kögler, Michal Šála, Pavla Plačková, Adriana Baumlová, Hubert Hřebabecký, Eliška Procházková, Milan Dejmek, Rémi Guillon, Dmytro Strunin, Jan Weber, Gary Lee, Gabriel Birkus, Helena Mertlíková-Kaiserová, Evzen Boura and Radim Nencka. J. Med. Chem., 2015, 58 (9), pp 3767–3793. DOI: 10.1021/acs.jmedchem.5b00499.

 

  1. Structural Basis for Oxygen Activation at a Heterodinuclear Manganese/Iron Cofactor. Julia J. Griese, Ramona Kositzki, Peer Schrapers, Rui M. M. Branca, Anders Nordström‖, Janne Lehtiö, Michael Haumann and Martin Högbom., JBC 290, 2015., pp 25254-25272.

 

  1. Evidence-Based Structural Model of the Staphylococcal Repressor Protein: Separation of Functions into Different Domains. Nyíri K, Kőhegyi B, Micsonai A, Kardos J and Vertessy BG. (2015) PLoS ONE 10(9): e0139086. doi:10.1371/journal.pone.0139086.

 

  1. Engineering a Nickase on the Homing Endonuclease I-DmoI Scaffold. Rafael Molina, María José Marcaida, Pilar Redondo, Marco Marenchino, Phillippe Duchateau, Marco D'Abramo, Guillermo Montoya and Jesús Prieto. JBC 290, July 24 2015., pp 18534-18544., doi: 10.1074/jbc.M115.658666 .

 

  1. Placing Molecules in a Cellular Context Using Light, Eelectron and X-Ray Microscopy. Lucy M. Collinson, (2015), Microscopy and Microanalysis Vol.21, pp 385. DOI: 10.1017/S143192761500272X.

 

  1. Structure of the Glycosyltransferase Ktr4p from Saccharomyces cerevisiae. Dominik D. D. Possner, Magnus Claesson and Jodie E. Guy., (2015) PLoS ONE 10(8): e0136239. doi:10.1371/journal.pone.0136239.

 

  1. Structure of mitochondrial poly(A) RNA polymerase reveals the structural basis for dimerization, ATP selectivity and the SPAX4 disease phenotype. Mikalai Lapkouski and B. Martin Hällberg. Nucl. Acids Res. (2015) doi: 10.1093/nar/gkv861.

 

  1. An integrated pipeline for sample preparation and characterization at the EMBL@PETRA3 synchrotron facilities. Stephane Boivin, Sandra Kozak, Gry Rasmussen, Ioana Maria Nemtanu, Vanessa Vieira and Rob Meijers.Methods, Available online 7 August 2015, ISSN 1046-2023, http://dx.doi.org/10.1016/j.ymeth.2015.08.003.

 

  1. Carborane-containing urea-based inhibitors of glutamate carboxypeptidase II: Synthesis and structural characterization. Sihyun Youn, Kyung Im Kim, Jakub Ptacek, Kiwon Ok, Zora Novakova, YunHye Kim, JaeHyung Koo, Cyril Barinka, Youngjoo Byun. Bioorganic & Medicinal Chemistry Letters, Available online 26 September 2015, ISSN 0960-894X, http://dx.doi.org/10.1016/j.bmcl.2015.09.062.

 

  1. Chorismatase Mechanisms Reveal Fundamentally Different Types of Reaction in a Single Conserved Protein Fold. Florian Hubrich, Puneet Juneja, Michael Müller, Kay Diederichs, Wolfram Welte and Jennifer N. Andexer. J. Am. Chem. Soc., 2015, 137 (34), pp 11032–11037, DOI: 10.1021/jacs.5b05559.

 

  1. Purification and crystallographic studies of a putative carbohydrate-binding module from the Ruminococcus flavefaciens FD-1 endoglucanase Cel5A. A. J. Pires, T. Ribeiro, A. Thompson, I. Venditto, V. O. Fernandes, P. Bule, H. Santos, V. D. Alves, V. Pires, L. M. A. Ferreira, C. M. G. A. Fontes and S. Najmudin. Acta Cryst. (2015). F71, pp 958-961., doi:10.1107/S2053230X15009784.
     
  1. Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2. Anastasia Mpakali, Petros Giastas, Nikolas Mathioudakis, Irene M. Mavridis, Emmanuel Saridakis and Efstratios Stratikos. (2015), JBC 290, pp 26021-26032.

 

  1. Transthyretin Binding Heterogeneity and Anti-amyloidogenic Activity of Natural Polyphenols and their Metabolites. Paola Florio, Claudia Folli, Michele Cianci, Daniele Del Rio, Giuseppe Zanotti and Rodolfo Berni., J Biol Chem. 2015 Oct 14.

 

  1. Structural Basis of Proline-Proline Peptide Bond Specificity of the Metalloprotease Zmp1 Implicated in Motility of Clostridium difficile. Schacherl, M., Pichlo, C., Neundorf, I., & Baumann, U. (2015). Structure, 23(9), pp 1632-1642.

 

  1. Structure of α-carbonic anhydrase from the human pathogen Helicobacter pylori. Compostella, M. E., Berto, P., Vallese, F., & Zanotti, G. (2015). Acta Crystallographica Section F: Structural Biology Communications, 71(8), pp 1005-1011.

 

  1. Structural evidence for asymmetric ligand binding to transthyretin. Cianci, M., Folli, C., Zonta, F., Florio, P., Berni, R., & Zanotti, G. (2015). Acta Crystallographica Section D: Biological Crystallography, 71(8), pp 1582-1592.

 

  1. High resolution structure of an M23 peptidase with a substrate analogue. Grabowska, M., Jagielska, E., Czapinska, H., Bochtler, M., & Sabala, I. (2015). Scientific reports, 5.

 

  1. The soluble Y115E–Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease. DiPisa, F., Pozzi, C., Benvenuti, M., Andreini, M., Marconi, G., & Mangani, S. (2015). Acta Crystallographica Section F: Structural Biology Communications, 71(8), pp 986-992.

 

  1. Crystal structure of the homing endonuclease I-CvuI provides a new template for genome modification. Rafael Molina, Pilar Redondo, Blanca López-Méndez, Maider Villate3, Nekane Merino, Francisco J. Blanco, Julien Valton, Silvestre Grizot, Phillippe Duchateau, Jesús Prieto and Guillermo Montoya (2015). Journal of Biological Chemistry, jbc-M115.

 

  1. KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA. Rajesh Ponnusamy, Maxim V. Petoukhov, Bruno Correia, Tania F. Custodio, Franceline Juillard, Min Tan, Marta Pires de Miranda, Maria A. Carrondo, J. Pedro Simas, Kenneth M. Kaye, Dmitri I. Svergun and Colin E. McVey.  Nucl. Acids Res. (2015) doi: 10.1093/nar/gkv987.

 

  1. Structure and Function of Caulobacter crescentus Aldose-aldose Oxidoreductase. Helena Taberman, Martina Andberg, Anu Koivula, Nina Hakulinen, Merja Penttilä, Juha Rouvinen and Tarja Parkkinen. Biochemical Journal Oct 05, 2015, ; DOI: 10.1042/BJ20150681.
     
  1. Two-step Ligand Binding in a (βα)8 Barrel Enzyme SUBSTRATE-BOUND STRUCTURES SHED NEW LIGHT ON THE CATALYTIC CYCLE OF HisASöderholm, A., Guo, X., Newton, M. S., Evans, G. B., Näsvall, J., Patrick, W. M., & Selmer, M. (2015). Journal of Biological Chemistry, 290(41), pp 24657-24668.

 

  1. The Pseudomonas aeruginosa Isohexenyl Glutaconyl Coenzyme A Hydratase (AtuE) Is Upregulated in Citronellate-Grown Cells and Belongs to the Crotonase Family. Poudel, N., Pfannstiel, J., Simon, O., Walter, N., Papageorgiou, A. C., & Jendrossek, D. (2015). Applied and environmental microbiology, 81(19), pp 6558-6566.

 

  1. Design of composite inhibitors targeting glutamate carboxypeptidase II: the importance of effector functionalities. Zora Novakova, Jiri Cerny, Cindy J. Choy, Jessie Nedrow, Joeseph K. Choi, Jacek Lubkowski, Clifford E. Berkman and Cyril Barinka., (2015). FEBS Journal.

 
 

  1. Structural Insights into Nonspecific Binding of DNA by TrmBL2, an Archaeal Chromatin Protein. Misbha Ud Din Ahmad, Ingrid Waege, Winfried Hausner, Michael Thomm, Winfried Boos, Kay Diederichs and Wolfram Welte. Journal of molecular biology, 427(20), pp 3216-3229.

 

  1. Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing. Anastasia Mpakali, Emmanuel Saridakis, Karl Harlos, Yuguang Zhao, Athanasios Papakyriakou, Paraskevi Kokkala, Dimitris Georgiadis and Efstratios Stratikos. The Journal of Immunology September 15, 2015 vol. 195 no. 6, pp 2842-2851.

 

  1. Nyíri, K., Papp-Kádár, V., Szabó, J. E., Németh, V., & Vértessy, B. G. Exploring the role of the phage-specific insert of bacteriophage Φ11 dUTPase. Structural Chemistry, 1-8.

 

  1. Structures of adenovirus incomplete particles clarify capsid architecture and show maturation changes of packaging protein L1 52/55k. Condezo, G. N., Marabini, R., Ayora, S., Carazo, J. M., Alba, R., Chillón, M., & San Martín, (2015), Journal of virology, 89(18), pp 9653-9664.

 

  1. Ligand Binding to Chlorite Dismutase from Magnetospirillum sp. Amy De Schutter, Hugo D. Correia, Diana M. Freire, María G. Rivas, Alberto Rizzi, Teresa Santos-Silva, Pablo J. González and Sabine Van Doorslaer. (2015), J. Phys. Chem. B, Article ASAP DOI: 10.1021/acs.jpcb.5b04141.

 

  1. Structural studies of Helix aspersa agglutinin complexed with GalNAc: a lectin that serves as a diagnostic tool. Pietrzyk, A. J., Bujacz, A., Mak, P., Potempa, B., & Niedziela, T. (2015).  International journal of biological macromolecules.

 

  1. Structural basis for antigen recognition by transglutaminase 2-specific autoantibodies in celiac disease. Chen, X., Hnida, K., Graewert, M. A., Andersen, J. T., Iversen, R., Tuukkanen, A., D., Svergun & Sollid, L. M. (2015). Journal of Biological Chemistry, 290(35), pp 21365-21375.

 

  1. A covalent homodimer probing early oligomers along amyloid aggregation. Halabelian, L., Relini, A., Barbiroli, A., Penco, A., Bolognesi, M., & Ricagno, S. (2015).Scientific reports, 5.

 

  1. Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase. Coelho, C., Foti, A., Hartmann, T., Santos-Silva, T., Leimkühler, S., & Romão, M. J. (2015). Nature chemical biology, 11(10), pp 779-783.

 

  1. Oligomerization of a Glucagon-like Peptide 1 Analog: Bridging Experiment and Simulations. Frederiksen, T. M., Sønderby, P., Ryberg, L. A., Harris, P., Bukrinski, J. T., Scharff-Poulsen, A. M.,Elf-Lind & Peters, G. H. (2015). Biophysical journal, 109(6), pp 1202-1213.

 

  1. A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures. Christiansen, G. B., Harbak, B., Hede, S. E., Gouliaev, A. H., Olsen, L., Frydenvang, K., Egebjerg, G., Kastrup, J . S. & Holm, M. M. (2015). Neuroscience.

 

  1. Iron binding to human heavy-chain ferritin. Pozzi, C., Di Pisa, F., Bernacchioni, C., Ciambellotti, S., Turano, P., & Mangani, S. (2015).  Acta Crystallographica Section D: Biological Crystallography, 71(9), pp 1909-1920.

 

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  1. The structure of Erb1-Ytm1 complex reveals the functional importance of a high-affinity binding between two β-propellers during the assembly of large ribosomal subunits in eukaryotes. Wegrecki, M., Rodríguez-Galán, O., de la Cruz, J., & Bravo, J. (2015). Nucleic acids research, gkv1043.

 

  1. Structure–Activity Relationship Study of Ionotropic Glutamate Receptor Antagonist (2 S, 3 R)-3-(3-Carboxyphenyl) pyrrolidine-2-carboxylic Acid. Krogsgaard-Larsen, N., Storgaard, M., Møller, C., Demmer, C. S., Hansen, J., Han, L., ... & Bunch, L. (2015). Journal of medicinal chemistry, 58(15), pp 6131-6150.

 

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  1. Forneris, Federico, Jin Wu, Xiaoguang Xue, Daniel Ricklin, Zhuoer Lin, Georgia Sfyroera, Apostolia Tzekou et al. "Regulators of complement activity mediate inhibitory mechanisms through a common C3b‐binding mode." The EMBO Journal (2016): e201593673.

 

  1. Silva, Catarina S., Xuelei Lai, M. Nanao, and C. Zubieta. "The Myb domain of LUX ARRHYTHMO in complex with DNA: expression, purification and crystallization." Acta Crystallographica Section F: Structural Biology Communications 72, no. 5 (2016).

 

  1. Chen, X., Hnida, K., Graewert, M. A., Andersen, J. T., Iversen, R., Tuukkanen, A., ... & Sollid, L. M. (2015). Structural basis for antigen recognition by transglutaminase 2-specific autoantibodies in celiac disease. Journal of Biological Chemistry, 290(35), 21365-21375.

 

  1. Basham, Mark, Jacob Filik, Michael T. Wharmby, Peter CY Chang, Baha El Kassaby, Matthew Gerring, Jun Aishima et al. "Data Analysis WorkbeNch (DAWN)." Journal of synchrotron radiation 22, no. 3 (2015): 853-858.

 

  1. Jones, Richard A., Xiaoping Yang, Shiqing Wang, Tyler King, Christopher James Kerr, Clement Blanchet, Dmitri Svergun et al. "Anisotropic Lanthanide-based Nano-clusters for Imaging Applications." Faraday Discussions (2016).

 

  1. Naylor, Claire E., Claire Bagnéris, Paul G. DeCaen, Altin Sula, Antonella Scaglione, David E. Clapham, and B. A. Wallace. "Molecular basis of ion permeability in a voltage‐gated sodium channel." The EMBO journal (2016): e201593285.

 

  1. Zhao, Yuguang, Jingshan Ren, Karl Harlos, and David I. Stuart. "Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions." FEBS letters (2016).

 

  1. Chiappi, Michele, José Javier Conesa, Eva Pereiro, Carlos Oscar Sánchez Sorzano, María Josefa Rodríguez, Katja Henzler, Gerd Schneider, Francisco Javier Chichón, and José L. Carrascosa. "Cryo-soft X-ray tomography as a quantitative three-dimensional tool to model nanoparticle: cell interaction." Journal of nanobiotechnology 14, no. 1 (2016): 1.

 

  1. Pahl, Axel, Markus Lakemeyer, Marie‐Theres Vielberg, Mathias W. Hackl, Jan Vomacka, Vadim S. Korotkov, Martin L. Stein et al. "Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association." Angewandte Chemie International Edition 54, no. 52 (2015): 15892-15896.

 

  1. Haikarainen, Teemu, Jo Waaler, Alexander Ignatev, Yves Nkizinkiko, Harikanth Venkannagari, Ezeogo Obaji, Stefan Krauss, and Lari Lehtiö. "Development and structural analysis of adenosine site binding tankyrase inhibitors." Bioorganic & medicinal chemistry letters 26, no. 2 (2016): 328-333.

 

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  1. Weiße, Renato H-J., Annette Faust, Marcel Schmidt, Peter Schönheit, and Axel J. Scheidig. "Structure of NDP-forming Acetyl-CoA synthetase ACD1 reveals a large rearrangement for phosphoryl transfer." Proceedings of the National Academy of Sciences (2016): 201518614.

 

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  1. Kiliszek, A., Banaszak, K., Dauter, Z. and Rypniewski, W., 2015. The first crystal structures of RNA–PNA duplexes and a PNA-PNA duplex containing mismatches—toward anti-sense therapy against TREDs. Nucleic acids research, p.gkv1513.

 
 

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  1. Monjas, L., Swier, L.J.Y.M., de Voogd, A.R., Oudshoorn, R.C., Hirsch, A.K.H. and Slotboom, D.J., 2016. Design and synthesis of thiamine analogues to study their binding to the ECF transporter for thiamine in bacteria. MedChemComm.

 

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  1. Louros, N.N., Chrysina, E.D., Baltatzis, G.E., Patsouris, E.S., Hamodrakas, S.J. and Iconomidou, V.A., 2016. A common “aggregation‐prone” interface possibly participates in the self‐assembly of human zona pellucida proteins. FEBS letters.

 

  1. Schacherl, M., Montada, A.A., Brunstein, E. and Baumann, U., 2015. The first crystal structure of the peptidase domain of the U32 peptidase family. Acta Crystallographica Section D: Biological Crystallography, 71(12), pp.2505-2512.

 

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  1. Ferraroni, M., Del Prete, S., Vullo, D., Capasso, C. and Supuran, C.T., 2015. Crystal structure and kinetic studies of a tetrameric type II β-carbonic anhydrase from the pathogenic bacterium Vibrio. Acta Cryst, 500, p.71

 

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  1. Han, H. and Kursula, P., 2015. The olfactomedin domain from gliomedin is a β-propeller with unique structural properties. Journal of Biological Chemistry, 290(6), pp.3612-3621.

 

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